21/FFP-P/10080

Novel Platinum-Based Mitocans for the Treatment of Resistant Cancers: Synthesis, Targeted Delivery and Biological Studies

In this project a new class of platinum-based cancer drugs will be developed that attack cancer cells via two distinct pathways simultaneously, DNA damage and interaction with the mitochondria.

The platinum drugs will be encapsulated into a nanocarrier which will be designed to target breast cancer. To further advance this work, we will synthesize a series of derivatives of C-Pt, study their structure-activity relationships and optimize the anticancer properties.

We will develop a new targeted nanocarrier to enhance the selectivity of the drug. We will investigate different targeting entities and evaluate the biological activity of the prodrug-nanocarrier systems.

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